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RO7486967

Parkinson's

RO7486967

Leeftijd icoon
50-85 years
Diagnose icoon
Parkinson's disease
Duratie onderzoek
14 weeks
Locatie icoon
Amsterdam and Zwolle

About this research

In order to participate in this study, you must be able to speak and read Dutch fluently.

The goal of this study is to evaluate how safe and tolerable the new study drug RO7486967 is for the treatment of participants with early stage Parkinson’s disease (with slowness of movement, and resting tremor or rigidity). The study compares the effect of the study drug RO7486967 with the effect of a placebo (a drug without an active ingredient, a ‘fake drug’). The study drug is administered orally.

Some researchers could show that people with Parkinson’s disease may have more inflammation in the brain. This is thought to be one of the reasons why people get Parkinson’s disease and why it progresses over time. A key part of the inflammation in the brain is a protein called NLRP3.  RO7486967 blocks NLRP3, and this blockage might lower the inflammation in the brain.

You will visit the research center approximately 11 times, during approximately 14 weeks. The duration of a visit is not always the same because not every visit has the same procedures. Some of these visits may last 10 hours, others 3.5 hours or shorter. The research takes place in Amsterdam or Zwolle. If you want, someone who knows you well or a family member can come with you during your visits

This research is commissioned by Roche.

How does the application process go?

You always decide whether you participate in a study. Participation is always voluntary.

  1. You apply via the online form, this is non-binding.
  2. After application, you are phoned, this is also an opportunity for you to ask questions. During this conversation, we also ask some questions to see whether you are eligible to participate in research. After this conversation, you determine whether you want to progress to step 3.
  3. You receive an email with the request to sign a document in which you give permission to retrieve your medical data.
  4. When your medical data shows that you meet the requirements to participate in the study, you are invited to a meeting at our location. During this meeting, you receive information and have the opportunity to ask questions, before you decide to participate in research.
  5. If you decide to participate in the study, you sign a form and will start the study within several weeks.

What are the benefits of Brain Research Center?

  1. You always come first – everything we do revolves around you.
  2. Experienced team of doctors, neuropsychologists, and nurses.
  3. Open and homely atmosphere – this will make you feel relaxed and right at home.
  4. Clarity – expert in medicine research which is why you will be well informed during all steps of the process and can always come to us for questions.
  5. Always nearby – 3 locations spread through the Netherlands.

What's in it for me?

  • You may experience benefits from a new treatment.
  • You will be monitored by a specialized team of healthcare professionals. They can give you advice and monitor whether there is a change in your daily functioning.
  • You make a meaningful contribution to a future without Alzheimer’s.
  • You contribute to the advancement of science.

Can I participate?

You can participate when:

  • You have Parkinson’s disease
  • You are between 50 and 85 years old.

Are you unsure whether you meet these requirements? Then you can always apply. We will then check together whether you are suitable to participate. 

Take action against Parkinson’s. Sign up to participate.

Latest Parkinson’s trials

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Parkinson's

LUMA

The goal of this study is to evaluate how safe and tolerable the new study drug RO7486967 is for the treatment of participants with early stage Parkinson’s disease (with slowness of movement, and resting tremor or rigidity). The study compares the effect of the study drug RO7486967 with the effect of a placebo (a drug without an active ingredient, a 'fake drug'). The study drug is administered orally.

audience30-80 years

levelEarly stage Parkinson's disease

duration55 to 151 weeks

locationAmsterdam and Zwolle

Parkinson's

RO7486967

The goal of this study is to evaluate how safe and tolerable the new study drug RO7486967 is for the treatment of participants with early stage Parkinson’s disease (with slowness of movement, and resting tremor or rigidity). The study compares the effect of the study drug RO7486967 with the effect of a placebo (a drug without an active ingredient, a 'fake drug'). The study drug is administered orally.

audience50-85 years

levelParkinson's disease

duration14 weeks

locationAmsterdam and Zwolle