Polaris AD

In order to participate in this study, you must be able to speak and read Dutch fluently.

The goal of this study is to evaluate the safety and efficacy of the new drug AR1001 for the treatment of patients with early Alzheimer’s disease. The study compares the effect of the new drug AR1001 with the effect of a placebo (a drug without an active ingredient, a ‘fake drug’). The study drug is taken orally in the form of a pill.

AR1001 might help brain cells grow, repair themselves, and communicate. This may slow or reverse early signs of Alzheimer’s disease and mild cognitive impairment and improve brain functions like memory.

The main study runs for approximately 1 year with the option to participate in an extension of the study for another year. During the extension of the study, participant will be administered with the study drug, no placebo. You and your study partner, someone who knows you well and can answer questions about your daily functioning, will visit the research center approximately 8 to 12 times, during approximately 1 to 2 years. The duration of a visit is not always the same because not every visit has the same procedures. Some of these visits may last about 2 hours, others about 5 hours. The research takes place in Amsterdam, Den Bosch or Zwolle.

This study is commissioned by AriBio

You always decide whether you participate in a study. Participation is always voluntary.

1. You apply via the online form, this is non-binding.
2. After application, you are phoned, this is also an opportunity for you to ask questions. During this conversation, we also ask some questions to see whether you are eligible to participate in research. After this conversation, you determine whether you want to progress to step 3.
3. You receive an email with the request to sign a document in which you give permission to retrieve your medical data.
4. When your medical data shows that you meet the requirements to participate in the study, you are invited to a meeting at our location. During this meeting, you receive information and have the opportunity to ask questions, before you decide to participate in research.
5. If you decide to participate in the study, you sign a form and will start the study within several weeks.

1. You always come first – everything we do revolves around you.
2. Experienced team of doctors, neuropsychologists, and nurses.
3. Open and homely atmosphere – this will make you feel relaxed and right at home.
4. Clarity – expert in medicine research which is why you will be well informed during all steps of the process and can always come to us for questions.
5. Always nearby – 3 locations spread through the Netherlands.

• You may experience benefits from a new treatment.
• You will be monitored by a specialized team of healthcare professionals. They can give you advice and monitor whether there is a change in your daily functioning.
• You make a meaningful contribution to a future without Alzheimer’s.
• You contribute to the advancement of science.

You can participate when:

• You have ‘Early Alzheimer’s disease (MCI or mild AD)’
• You are between 55 and 90 years old
• You have someone close to you/a caregiver who can accompany you during the visits to the research center and can answer questions about your health and functioning, among other things.

Are you unsure whether you meet these requirements? Then you can always apply. We will then check together whether you are suitable to participate.